Rapid pain modulation with nuclear receptor ligands
نویسندگان
چکیده
منابع مشابه
What are nuclear receptor ligands?
Nuclear receptors (NRs) are a family of highly conserved transcription factors that regulate transcription in response to small lipophilic compounds. They play a role in every aspect of development, physiology and disease in humans. They are also ubiquitous in and unique to the animal kingdom suggesting that they may have played an important role in their evolution. In contrast to the classical...
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Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7 alpha-hydroxylase, which is the rate-lim...
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Cholestasis is a clinical syndrome resulting from disturbed bile formation. The etiology includes different diseases ranging from genetic defects in hepatocellular bile formation to inflammatory diseases of the bile ducts. Many cholestatic diseases are progressive and ultimately fatal. Whatever the cause, cholestasis results in intrahepatic accumulation of cytotoxic bile acids which lead to liv...
متن کاملpain and modulation processes
pain is one of the most important and sometimes difficult problems, that patients and physicians are encountered. it may be clinically acute or chronic, acute pain has usually definite cause and favourable response to treatment. on the other hand there are difficulties in diagnosis and management of chronic pain. peripheral and cranial nerves convey pain impulses toward central nervous system, ...
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Recognition of specific pathogen associated molecular patterns (PAMPs) is mediated primarily by members of the Toll-like receptor (TLR) family. Stimulation through these receptors results in quantitative and qualitative changes in antigen presentation and cellular activation, thereby linking innate and adaptive immunity. Consequently, the incorporation of TLR-ligands into vaccines could result ...
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ژورنال
عنوان ژورنال: Brain Research Reviews
سال: 2009
ISSN: 0165-0173
DOI: 10.1016/j.brainresrev.2008.12.019